Melanotan 2 dosage figures describe tests, not your care.

An amount from a study wasn't chosen for your body

At first, you may read a study figure as an instruction. It isn't, and you won't get directions for using Melanotan 2 here.

The figures let you see what researchers gave a person, mouse, or rat. Melanotan 2 isn't approved for anyone's use ^[4].

You'll see that a few small human tests used shots just below the skin. Animal tests used that route, a vein, or a needle placed in the brain.

Doctors use half life for the period in which half a drug leaves the blood. No sound human study can tell you that time for Melanotan 2.

Here's how I'd read each amount: it's a fact about one old test. Small studies and uncertain online vials make poor guides for your body.

Every study chose a different amount for its own test

Past studies supply every figure on this list. None is a guide for giving yourself a shot.

• 1996, skin study in men: researchers began at 0.01 milligrams for every kilogram a man weighed each day, then raised it to 0.025-0.03 milligrams per kilogram per day. They chose 0.025 milligrams per kilogram per day for more study ^[1]; 0.03 milligrams per kilogram caused too much sleepiness.
• 1998, erection study in men: each man received one shot of 0.025 milligrams per kilogram below the skin ^[2]. Doctors found no physical cause for their erection trouble; worry or other mental strain was thought to play a part.
• 2003, nerve study in rats: 20 millionths of a gram per kilogram below the skin helped every 48 hours. Amounts of 2 and 50 millionths of a gram per kilogram didn't help, so more wasn't better ^[7].
• 2022, hunger study in mice: researchers put 0.1-1 nanomoles into a reward area deep in the brain ^[5]. Nanomoles count drug particles in a lab, so you can't compare the figure with a spoonful or shot.

Nausea grew worse as amounts rose in the human work. About 13% of people had severe nausea at 0.025 milligrams per kilogram ^[2].

The Melanotan 2 half life in people remains unknown

You won't find a good human study giving the half life of Melanotan 2. In one rat test, the amount in blood fell quickly and then slowed.

Researchers have timed afamelanotide, also called Melanotan I, in people. That's a different drug, so its timing can't tell your doctor how long this one stays in you.

For you, the melanotan 2 half life is separate from how long skin stays brown. Skin cells may keep making color after your blood no longer carries the drug.

In 2026, some brown color remained in one man's mouth at 3 months after he stopped ^[31]. His case can't tell you when your own color would fade.

Melanotan 2 injections took several routes in studies

You can see several ways researchers put the drug into the body. The list describes tests and reports; it isn't a set of choices for you.

• A shot just below the skin. Most human studies and doctors' reports about melanotan 2 injections used this route. In rats, very little reached the blood after they swallowed the drug.
• A shot into a vein. Researchers used this route in rats while watching their brain cells and actions ^[8]. The drug entered the blood at once.
• A shot into the brain. Researchers studying mice or rats used this route for hunger, body heat, and energy use ^[5]. It hasn't been tested as a normal route for people.
• A spray in the nose. You may read reports that some people used the drug this way ^[31]. No licensed safety study has shown the spray to be safe.

Online sellers often provide a dry powder that needs mixing. You won't find mixing, storage, or injection steps on this page.